Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Proteomics01:33

Proteomics

7.5K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
7.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sphingosine-1-phosphate receptor modulators resensitize FLT3-ITD acute myeloid leukemia cells with NRAS mutations to FLT3 inhibitors.

Leukemia·2026
Same author

Glutamine-dependent downregulation of FLT3-ITD is a mechanism of FLT3 inhibitor resistance in FLT3-ITD AML in hypoxia.

bioRxiv : the preprint server for biology·2026
Same author

Stk1 is required for BlaR1-mediated broad-spectrum β-lactam resistance in epidemic-causing strains of <i>Staphylococcus aureus</i>.

Research square·2026
Same author

Extracellular Vesicle Associated Proteomic Biomarkers in Breast Cancer: A Systematic Review and Meta-Analysis.

Cells·2026
Same author

Stem cell-based strategies for HIV-1 remission: Emerging frontiers and translational challenges.

Archives of stem cell and therapy·2026
Same author

HIV-1 and Artificial Intelligence: From Molecular Insight to Population Impact.

Journal of AIDS and HIV treatment·2025

Related Experiment Video

Updated: May 5, 2026

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes
09:10

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes

Published on: May 22, 2018

10.6K

Plasma Proteome Database as a resource for proteomics research: 2014 update.

Vishalakshi Nanjappa1, Joji Kurian Thomas, Arivusudar Marimuthu

  • 1Institute of Bioinformatics, International Technology Park, Bangalore 560 066, Karnataka, India, Amrita School of Biotechnology, Amrita University, Kollam 690 525, Kerala, India, Centre of Excellence in Bioinformatics, School of Life Sciences, Pondicherry University, Puducherry 605 014, India, Department of Biochemistry and Molecular Biology, Pondicherry University, Puducherry 605014, India, Department of Neurochemistry, National Institute of Mental Health and Neurosciences, Bangalore 560 022, Karnataka, India, Department of Biotechnology, Kuvempu University, Shankaraghatta 577 451, Karnataka, India, Government Medical College, Bhavnagar 364 001, Gujarat, India, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Wardha 442 012, Maharashtra, India, The Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA, Department of Internal Medicine, Armed Forces Medical College, Pune 411 040, Maharashtra, India, Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore 560 022, Karnataka, India, Department of Biochemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria 3084, Australia, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, MD 21205, USA, Department of Biological Chemistry, Johns Hopkins University, Baltimore, MD 21205, USA, Department of Oncology, Johns Hopkins University, Baltimore, MD 21205, USA and Department of Pathology, Johns Hopkins University, Baltimore, MD 21205, USA.

Nucleic Acids Research
|December 6, 2013
PubMed
Summary

The Plasma Proteome Database now includes over 10,500 human plasma proteins, with enhanced data including mass spectrometry results and concentrations. This resource accelerates biomarker discovery and translation in clinical and basic research.

More Related Videos

Mass Spectrometry-Based Proteomics Analyses Using the OpenProt Database to Unveil Novel Proteins Translated from Non-Canonical Open Reading Frames
07:38

Mass Spectrometry-Based Proteomics Analyses Using the OpenProt Database to Unveil Novel Proteins Translated from Non-Canonical Open Reading Frames

Published on: April 11, 2019

14.8K
Navigating the Mass Spectrometry-Based Proteomic Data Using Free Computational Tools
07:01

Navigating the Mass Spectrometry-Based Proteomic Data Using Free Computational Tools

Published on: August 19, 2025

1.2K

Related Experiment Videos

Last Updated: May 5, 2026

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes
09:10

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes

Published on: May 22, 2018

10.6K
Mass Spectrometry-Based Proteomics Analyses Using the OpenProt Database to Unveil Novel Proteins Translated from Non-Canonical Open Reading Frames
07:38

Mass Spectrometry-Based Proteomics Analyses Using the OpenProt Database to Unveil Novel Proteins Translated from Non-Canonical Open Reading Frames

Published on: April 11, 2019

14.8K
Navigating the Mass Spectrometry-Based Proteomic Data Using Free Computational Tools
07:01

Navigating the Mass Spectrometry-Based Proteomic Data Using Free Computational Tools

Published on: August 19, 2025

1.2K

Area of Science:

  • Proteomics
  • Biochemistry
  • Bioinformatics

Background:

  • The Human Plasma Proteome Project (HPPP) initiated the Plasma Proteome Database (PPD) in 2005.
  • Advancements in proteomic technologies have significantly increased the number of identified plasma proteins.
  • Existing databases required enrichment to accommodate new proteomic data.

Purpose of the Study:

  • To update and expand the Plasma Proteome Database (PPD) with recent proteomic findings.
  • To incorporate mass spectrometry data and protein concentration information.
  • To provide a tool for assessing the novelty of experimental data sets in plasma proteomics.

Main Methods:

  • Data aggregation from proteomic studies.
  • Inclusion of mass spectrometry-derived data, including proteotypic peptides.
  • Development of the Plasma Proteome Explorer for batch queries.

Main Results:

  • The PPD now contains information on 10,546 proteins detected in human serum/plasma.
  • 3,784 proteins are reported in two or more studies.
  • Includes published concentrations for 1,278 proteins and a category for extracellular vesicle proteins.

Conclusions:

  • The enriched PPD serves as a comprehensive reference for human plasma proteins.
  • The database facilitates biomarker discovery and translation in clinical and basic research.
  • The Plasma Proteome Explorer aids researchers in evaluating the novelty of their proteomic data.