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Human T-lymphotropic virus/HIV co-infection: a clinical review
Divya Dhasmana1, Graham P Taylor
1aNational Centre for Human Retrovirology, Imperial College Healthcare NHS Trust, St Mary's Hospital bSection of Infectious Diseases, Imperial College, Norfolk Place, London, UK.
Purpose Of Review:
Human T-lymphotropic virus (HTLV)/HIV co-infections are often undiagnosed, with important clinical implications. The literature is relatively sparse with key observations derived in the pre-highly-active antiretroviral therapy era.
Recent Findings:
The epidemiology of co-infection, the impact of each virus on the other, with particular reference to clinical manifestations and the impact of antiretroviral therapy on HTLVs are described.
Summary:
Important clinical effects of HTLV/HIV co-infection include the higher rates of myelopathy and other neurological disorders and the poor predicative value of CD4+ cell counts as a surrogate for immune suppression. Current antiretroviral therapies in isolation have no proven effect on HTLV-1/2 proviral load.
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