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Updated: May 5, 2026

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Subclinical nephrosclerosis is linked to left ventricular hypertrophy independent of classical atherogenic factors

Naoki Haruyama1, Akihiro Tsuchimoto1, Kosuke Masutani1

  • 1Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Hypertension Research : Official Journal of the Japanese Society of Hypertension
|December 6, 2013
PubMed

Insights

Subclinical kidney damage, indicated by global glomerulosclerosis (GGS), is linked to left ventricular hypertrophy (LVH) even in individuals with normal kidney function. Higher GGS levels significantly increase the risk of developing LVH.

Area of Science:

  • Cardiology
  • Nephrology
  • Renal Function

Background:

  • Cardio-renal interactions are increasingly recognized as significant.
  • Mild renal dysfunction is linked to left ventricular hypertrophy (LVH).
  • The relationship between LVH and subclinical renal damage remains unclear.

Purpose of the Study:

  • To investigate the association between subclinical renal damage and LVH.
  • To assess the correlation between global glomerulosclerosis (%GGS) and LVH in living kidney donors with normal renal function.

Main Methods:

  • Retrospective analysis of 238 living kidney donor pretransplant biopsies.
  • Categorization of donors into tertiles based on %GGS.
  • Measurement of left ventricular mass index (LVMI) by echocardiography.
  • Logistic regression analysis to evaluate the correlation between %GGS and LVH.

Main Results:

  • LVMI and the prevalence of left ventricular remodeling and LVH increased significantly with higher tertiles of %GGS.
  • High %GGS tertiles were associated with a sevenfold greater risk of LVH compared to low tertiles.
  • This association remained significant after adjusting for age, sex, blood pressure, GFR, and other atherogenic factors.

Conclusions:

  • An association exists between global glomerulosclerosis and left ventricular hypertrophy in individuals with normal renal function.
  • Subclinical renal damage, indicated by GGS, is a significant risk factor for LVH.
  • These findings highlight the importance of considering renal health in cardiovascular risk assessment.

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