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Evaluating DAPK as a therapeutic target

Yide Huang1, Ling Chen, Libin Guo

  • 1Fujian Key Laboratory of Developmental and Neural Biology, College of Life Sciences, Fujian Normal University, Fuzhou, 350108, Fujian, People's Republic of China.

Apoptosis : an International Journal on Programmed Cell Death
|December 6, 2013
PubMed

Insights

Death associated protein kinase 1 (DAPK) is a key kinase in cellular processes. Its dysregulation, often via gene methylation in cancer, presents therapeutic opportunities.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Background:

  • Death associated protein kinase 1 (DAPK) is a serine/threonine kinase crucial for apoptosis, autophagy, and inflammation.
  • Misregulation of DAPK is implicated in diseases like cancer and neuronal death.
  • Gene methylation frequently silences DAPK in various cancers, leading to expression loss.

Purpose of the Study:

  • To review the pathological roles and functions of DAPK in disease.
  • To compare reagents that modulate DAPK expression or activity.
  • To discuss the potential and challenges of targeting DAPK therapeutically.

Main Methods:

  • Literature review of DAPK's role in disease.
  • Analysis of DAPK-targeting reagents.
  • Discussion of clinical application barriers and opportunities.

Main Results:

  • DAPK plays diverse roles in cellular processes and disease pathology.
  • Various reagents exist to manipulate DAPK expression and activity.
  • DAPK's complex functions present both therapeutic potential and challenges.

Conclusions:

  • DAPK is a significant factor in disease pathogenesis.
  • Targeting DAPK offers potential therapeutic avenues.
  • Further research is needed to overcome barriers for clinical application.

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