A Novel Quinazolinone Derivative as Fluorescence Quenching Off-On Sensor for High Selectivity of Fe(3+)

A novel quinazolinone compound containing quinazoline-fused moiety has been synthesized as fluorescence Off-On sensor QQ. The probe exhibited highly selective and sensitive recognition toward trivalent ferric ion (Fe(3+)) over other metal ions in HEPES buffer solution (10 mM, pH = 7.0, DMF-H2O, 9:1, v/v). The significant quenching in the fluorescence spectral could be served as a selective fluorescence Off-On sensor. The titration study indicated the formation of 1:1 complex between QQ and Fe(3+).