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Updated: Jan 14, 2026
Targeted Antibody Blocking by a Dual-Functional Conjugate of Antigenic Peptide and Fc-III Mimetics DCAF
Published on: September 17, 2019
Antibody-mediated functional control of a dansylated polytheonamide mimic
1Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. inoue@mol.f.u-tokyo.ac.jp.
Abstract:
We demonstrate the functional control of a dansylated polytheonamide mimic (2), an artificial ion channel-forming cytotoxic peptide, by the external addition of a polyclonal anti-dansyl antibody (anti-dansyl IgG). The IgG effectively suppressed the ion transport activity and cytotoxicity of 2 in a dose-dependent manner.
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