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Elevated preoperative systemic inflammatory markers predict poor outcome in localized soft tissue sarcoma.

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  • 1Department of Orthopaedic Surgery, Seoul National University Hospital, Seoul, Korea.

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|December 6, 2013
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Preoperative systemic inflammation markers like C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) can predict disease-specific survival in soft tissue sarcoma (STS) patients. Elevated multiple markers showed greater prognostic significance than single markers.

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Area of Science:

  • Oncology
  • Inflammation Research
  • Surgical Outcomes

Background:

  • Systemic inflammation is linked to cancer development and progression.
  • Investigating predictive markers for soft tissue sarcoma (STS) outcomes is crucial.

Purpose of the Study:

  • To determine if preoperative systemic inflammatory markers predict postoperative outcomes in soft tissue sarcoma (STS).
  • To evaluate the association of C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and neutrophil-to-lymphocyte ratio (NLR) with disease-specific survival and local recurrence in STS patients.

Main Methods:

  • A retrospective review of 162 primary, localized STS cases.
  • Exclusion of patients with infectious or inflammatory diseases.
  • Analysis of serum CRP, ESR, and NLR levels measured preoperatively for association with survival and recurrence over a mean follow-up of 46.7 months.

Main Results:

  • Univariate analysis showed all markers (CRP, ESR, NLR) associated with disease-specific survival.
  • Multivariate analysis confirmed CRP and ESR as significant predictors.
  • Elevated multiple markers were more significant prognostic factors (P = 0.001); no markers predicted local recurrence.
  • Histologic grade strongly correlated with inflammatory marker values.

Conclusions:

  • Preoperative systemic inflammatory status, assessed by multiple serum markers, predicts disease-specific survival in STS.
  • CRP and ESR are significant independent predictors of survival in STS patients.