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Should we consider patients with coexistent hepatitis B or C infection for orthotopic heart transplantation?

Baskar Sekar1, Pippa J Newton, Simon G Williams

  • 1The Transplant Centre, Wythenshawe Hospital, University Hospital of South Manchester NHS Foundation Trust, Manchester M23 9LT, UK.

Journal of Transplantation
|December 6, 2013
PubMed

Insights

Heart transplantation (HTX) is a vital treatment for advanced heart failure. This review examines the outcomes of HTX in patients with hepatitis B or C, considering new antiviral therapies.

Area of Science:

  • Cardiology
  • Hepatology
  • Transplantation Medicine

Background:

  • Heart transplantation (HTX) is the primary treatment for end-stage heart failure.
  • Hepatitis B and C infections affect over 10% of HTX recipients.
  • Long-term outcomes for HTX patients with hepatitis B/C are not well-established.

Purpose of the Study:

  • To review existing literature on HTX outcomes in patients with hepatitis B/C.
  • To evaluate the justification for listing these patients for HTX.
  • To explore the impact of new antiviral therapies on this cohort.

Main Methods:

  • Literature review of studies on heart transplantation and hepatitis B/C.
  • Analysis of patient outcomes, viral reactivation, and liver disease progression.
  • Assessment of current and emerging antiviral treatment efficacy.

Main Results:

  • Data on long-term outcomes for HTX recipients with hepatitis B/C is limited.
  • Concerns exist regarding increased viral reactivation and liver disease post-transplant.
  • New antiviral therapies show promise but require further long-term outcome data.

Conclusions:

  • Listing advanced heart failure patients with hepatitis B/C for HTX remains a complex decision.
  • Careful patient selection and management are crucial.
  • Further research is needed to establish long-term safety and efficacy of HTX with modern antiviral treatments.

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