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Published on: March 6, 2018
Is bilateral orchiectomy for metastatic prostate cancer treatment associated with high cardiovascular risk?
Konstantinos Stamatiou1, Eleni Stamatopoulou, George Christopoulos
1General Hospital "TZANEIO", Piraeus, Greece.
Insights
Low testosterone levels may increase cardiovascular disease (CVD) risk in men. This study examines two cases where androgen deprivation therapy potentially exacerbated CVD, leading to fatal strokes.
Area of Science:
- Cardiology
- Endocrinology
- Oncology
Background:
- Cardiovascular disease (CVD) is a leading cause of mortality globally, particularly in Western populations.
- While traditionally attributed to testosterone's negative effects, emerging evidence suggests potential cardioprotective roles for testosterone.
- Low testosterone levels are increasingly linked to elevated CVD risk, morbidity, and mortality in men.
Observation:
- This article details two male patients with existing CVD and metastatic prostate cancer.
- Both patients underwent bilateral orchiectomy as part of their prostate cancer treatment.
- Tragically, both patients experienced fatal acute strokes during the perioperative period.
Findings:
- The cases suggest a potential link between androgen deprivation and accelerated cardiovascular disease progression.
- The perioperative stroke events highlight a possible increased risk associated with this therapeutic approach.
Implications:
- Further research is warranted to elucidate the complex relationship between testosterone, androgen deprivation, and cardiovascular health.
- Clinical management of male patients with CVD and prostate cancer requires careful consideration of hormonal therapies and their cardiovascular risks.
Abstract:
Cardiovascular disease is one of the most common causes of death worldwide and the most usual in the western populations. Although it affects both sexes, it is more frequent in males in whom it shortens the average life expectancy. This difference has been attributed to the negative effects of testosterone; however, recent research showed that this hormone may have protective effects on the cardiovascular system. In confirmation to the above current evidence suggests that the low levels of testosterone could be associated with an increased CVD risk and with an augmentation of morbidity and mortality in males. In the present article, we present 2 cases of men with CVD and metastatic prostate cancer treated with bilateral orchiectomy who died of acute stroke during the perioperational period. The possible association of androgen deprivation with cardiovascular disease progression and the consequent risk of stroke are briefly discussed.
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