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The spread and acquisition of NDM-1: a multifactorial problem
Alexander M Wailan1, David L Paterson
1The University of Queensland, UQ Centre for Clinical Research, Herston QLD 4029, Australia.
Expert Review of Anti-Infective Therapy
|December 7, 2013
Summary
New Delhi metallo-β-lactamase (NDM) is a growing threat, causing Gram-negative bacteria resistance to crucial antibiotics. Urgent global action is needed to control its spread and prevent untreatable infections.
Area of Science:
- Microbiology
- Infectious Diseases
- Antimicrobial Resistance
Background:
- New Delhi metallo-β-lactamase (NDM) is a significant mechanism of resistance in Gram-negative bacteria against β-lactam antibiotics.
- NDM-producing bacteria, particularly Enterobacteriaceae and Acinetobacter spp., have spread globally at an alarming rate.
Purpose of the Study:
- To highlight the global spread and implications of New Delhi metallo-β-lactamase (NDM) producing Gram-negative bacteria.
- To emphasize the limited treatment options and the emerging threat of polymyxin resistance.
Main Methods:
- This study is a review and synthesis of current knowledge on NDM.
- Analysis of factors contributing to the global dissemination of NDM-producing organisms.
Main Results:
- NDM confers resistance to carbapenems and other β-lactams in a wide range of Gram-negative bacteria.
- A combination of human and bacterial factors drives the rapid global spread of NDM.
- Treatment for NDM infections is limited, with polymyxins often used in combination therapy, but polymyxin resistance is a growing concern.
Conclusions:
- The global spread of NDM-producing bacteria poses a severe threat to modern medicine.
- International collaboration and enhanced stewardship are critical to control NDM dissemination.
- Failure to control NDM could lead to untreatable infections, undermining medical advances.
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