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Immunologic and nonimmunologic responsiveness in ragweed-sensitized dogs
Journal of Applied Physiology (Bethesda, Md. : 1985)
|October 1, 1986
Summary
Allergic airway reactions in dogs depend on both immune responses and non-immune airway sensitivity to histamine. These factors are inversely related, influencing how airways react to inhaled allergens.
Area of Science:
- Allergy and Immunology
- Pulmonary Medicine
- Veterinary Medicine
Background:
- Allergic airway diseases involve complex immune responses.
- Understanding the interplay between immunologic and non-immunologic factors is crucial for managing airway hyperresponsiveness.
Purpose of the Study:
- To investigate the relationship between airway responsiveness, immunologic factors, and histamine sensitivity in allergic dogs.
- To determine the correlation between airway reactions to inhaled antigen and histamine.
Main Methods:
- Examined airway responsiveness to antigen and histamine (ED200) in allergic and control dogs.
- Assessed immunologic responsiveness including skin tests, specific immunoglobulin E (IgE) antibodies, and lung histamine release.
- Analyzed correlations between various immunologic and airway responsiveness parameters.
Main Results:
- Significant correlations were found between airway responsiveness and cutaneous responsiveness, IgE levels, and lung histamine release.
- An inverse correlation existed between immunologic responsiveness and non-immunologic airway responsiveness (histamine ED200) in ragweed-sensitized dogs.
- Antigen ED200 was significantly correlated with histamine release from the lung post-antigen inhalation.
Conclusions:
- Airway reactions to inhaled allergens in allergic dogs are influenced by both immunologic factors and non-immunologic airway responsiveness to histamine.
- These immunologic and non-immunologic factors exhibit an inverse correlation, suggesting a complex regulatory mechanism in allergic airway disease.