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Related Concept Videos

Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants01:18

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Updated: May 5, 2026

Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood
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[Warfarin-related nephropathy: a case report].

L Zerah1, I Brochériou2, P Galichon3

  • 1Urgences néphrologiques et transplantation rénale, hôpital Tenon, AP-HP, 4, rue de la Chine, 75020 Paris, France.

La Revue De Medecine Interne
|December 7, 2013
PubMed
Summary

Warfarin-related nephropathy (WRN) can occur with supratherapeutic warfarin levels (INR > 3). Prompt diagnosis and vitamin K administration are crucial for managing this kidney injury.

Keywords:
Acute kidney injuryAnti-vitamine KCoumadineInsuffisance rénale aiguëVitamin K deficiencyWarfarin

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Area of Science:

  • Nephrology
  • Hematology
  • Pharmacology

Background:

  • Warfarin-related nephropathy (WRN) is a condition caused by excessive warfarin use, leading to kidney tubule blockage by red blood cells.
  • This occurs after glomerular bleeding in patients with an international normalized ratio (INR) above 3.

Observation:

  • A 70-year-old male with no prior kidney issues developed WRN.
  • His condition arose when his INR exceeded 12.
  • The patient did not regain his baseline renal function post-event.

Findings:

  • WRN diagnosis should be suspected in warfarin-exposed patients with INR > 3, especially if hematuria is present.
  • Vitamin K is identified as the sole therapeutic intervention.

Implications:

  • Highlights the importance of vigilant INR monitoring in warfarin patients to prevent acute kidney injury.
  • Emphasizes the critical role of vitamin K in managing warfarin-induced nephrotoxicity.