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[Long-term results after trabeculectomy with 5-fluorouracil].
A Koutsonas1, A Remky, N Plange
1Augenklinik, Universitätsklinikum Aachen, Pauwelsstr. 30, 52057, Aachen, Deutschland, akoutsonas@ukaachen.de.
Summary
Trabeculectomy with 5-fluorouracil (5-FU) demonstrates high success rates in managing glaucoma, offering a viable alternative to mitomycin C. This surgical approach effectively lowers intraocular pressure with minimal serious complications.
Area of Science:
- Ophthalmology
- Surgical Glaucoma Treatment
- Pharmacological Adjuncts
Context:
- Glaucoma management often involves surgical intervention.
- Trabeculectomy is a primary surgical option for glaucoma.
- Antimetabolites like mitomycin C enhance trabeculectomy success rates.
Purpose:
- To evaluate the efficacy and safety of trabeculectomy utilizing 5-fluorouracil (5-FU).
- To present surgical outcomes for glaucoma patients treated with 5-FU.
Summary:
- A retrospective analysis of 71 trabeculectomies with 5-FU in decompensated glaucoma patients was conducted.
- High success rates in reducing intraocular pressure (IOP) were observed at 6 months and 1 year.
- Postoperative interventions included subconjunctival 5-FU or needling procedures, with few serious complications.
Impact:
- Trabeculectomy with intraoperative 5-FU shows significant potential for glaucoma treatment.
- This method offers comparable results to mitomycin C, expanding therapeutic options.
- The study highlights the effectiveness of 5-FU as an adjunct in glaucoma surgery.
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