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The relationship between serum mannose-binding lectin levels and acute ischemic stroke risk
Zhen-Yu Wang1, Zhong-Ren Sun, Li-Ming Zhang
1The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, People's Republic of China.
Neurochemical Research
|December 7, 2013
Summary
Elevated mannose-binding lectin (MBL) levels are linked to a higher risk of acute ischemic stroke (AIS) in the Chinese population. Higher MBL serum levels correlate with stroke severity, suggesting MBL is an independent stroke risk factor.
Area of Science:
- Immunology
- Neurology
- Genetics
Background:
- Complement activation and inflammation are implicated in stroke pathogenesis.
- Mannose-binding lectin (MBL) plays a role in these inflammatory processes.
Purpose of the Study:
- To investigate the association between serum MBL levels and acute ischemic stroke (AIS) in a Chinese population.
- To determine if MBL is an independent risk factor for AIS.
Main Methods:
- Serum MBL levels and routine tests were analyzed in 148 first-ever AIS patients and normal controls.
- National Institutes of Health Stroke Scale (NIHSS) scores were assessed.
- Multivariate analysis was performed to identify independent risk factors.
Main Results:
- Serum MBL levels were significantly higher in AIS patients compared to controls (p < 0.0001).
- A significant correlation was found between serum MBL levels and NIHSS scores (r = 0.608, p < 0.0001).
- Elevated MBL was independently associated with an increased risk of AIS (OR 1.002, p < 0.0001).
Conclusions:
- Elevated serum MBL levels are an independent risk factor for AIS in the Chinese population.
- MBL and the lectin pathway of complement activation may contribute to stroke pathogenesis.
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