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Increased systemic oxidative stress in patients with keratoconus
I Toprak1, V Kucukatay2, C Yildirim3
1Department of Ophthalmology, Servergazi State Hospital, Denizli, Turkey.
Eye (London, England)
|December 7, 2013
Summary
Systemic oxidative stress, indicated by higher total oxidant status (TOS) and oxidative stress index (OSI), may contribute to the development of keratoconus. Antioxidant levels (TAS) showed no significant difference.
Area of Science:
- Ophthalmology
- Biochemistry
- Corneal Diseases
Background:
- Keratoconus is a progressive thinning of the cornea.
- The role of systemic factors in keratoconus pathogenesis is increasingly recognized.
- Oxidative stress is implicated in various degenerative diseases.
Purpose of the Study:
- To investigate the association between systemic oxidative stress and keratoconus.
- To measure serum total oxidant status (TOS) and total antioxidant status (TAS) in keratoconus patients.
Main Methods:
- A case-control study involving 25 keratoconus patients and 25 healthy controls.
- Exclusion of participants with confounding factors like smoking or systemic inflammation.
- Measurement of serum TOS, TAS, and calculation of oxidative stress index (OSI).
Main Results:
- Patients with keratoconus exhibited significantly higher serum TOS and OSI compared to controls.
- No significant difference in serum TAS was observed between the groups.
- Mean age and sex distribution were comparable between keratoconus and control groups.
Conclusions:
- Elevated systemic oxidant status and OSI in keratoconus patients suggest a potential role for oxidative stress in the disease's pathogenesis.
- Further research is warranted to explore the therapeutic implications of targeting oxidative stress in keratoconus.
