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Nailfold capillary abnormalities in erectile dysfunction of systemic sclerosis: a EUSTAR group analysis.

Andrea D Keck1, Chingching Foocharoen, Edoardo Rosato

  • 1Department of Rheumatology, Basel University, Burgfelderstrasse 101, CH 4012 Basel, Switzerland. ulrich.walker@usb.ch.

Rheumatology (Oxford, England)
|December 7, 2013
PubMed
Summary

Nailfold capillary abnormalities are not linked to erectile dysfunction (ED) in men with systemic sclerosis (SSc). This study found no association between capillaroscopy patterns and ED presence or severity in SSc patients.

Keywords:
ageingerectile dysfunctionnailfold capillaroscopypathogenesisscleroderma patternsystemic sclerosisvasculopathy

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Area of Science:

  • Rheumatology
  • Urology
  • Dermatology

Background:

  • Systemic sclerosis (SSc) is a multisystem autoimmune disease that can affect various organs.
  • Erectile dysfunction (ED) is a common complication in men with SSc, potentially impacting quality of life.
  • Nailfold capillaroscopy is a non-invasive technique used to assess microvascular changes in SSc.

Purpose of the Study:

  • To investigate the association between nailfold capillary abnormalities and the presence and severity of ED in men diagnosed with SSc.
  • To determine if specific capillaroscopy patterns correlate with ED in this patient population.

Main Methods:

  • A cross-sectional analysis was conducted using data from the European League Against Rheumatism (EULAR) Scleroderma Trial and Research database.
  • Men with SSc underwent nailfold capillaroscopy and completed the 5-item International Index for Erectile Function (IIEF-5) questionnaire.
  • Eighty-six men met the inclusion criteria for the study.

Main Results:

  • Of 78 men with an IIEF-5 score, 88.5% had nailfold capillary abnormalities, and 78.3% of those experienced ED.
  • No significant difference in ED prevalence was found between men with and without nailfold capillary abnormalities (P = 0.44).
  • ED was more frequent in older men and those with diffuse SSc. Abnormal capillaroscopy correlated with higher disease activity, lower lung diffusing capacity, and higher skin scores, but mean IIEF-5 scores did not differ.

Conclusions:

  • The presence or absence of abnormal nailfold capillaroscopy findings is not associated with coexistent ED in men with SSc.
  • Subdivision of capillaroscopy patterns into early, active, or late does not correlate with the presence or severity of ED in SSc patients.