Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Allergic contact dermatitis: novel immunohistologic features.

G S Wood, A S Volterra, E A Abel

    The Journal of Investigative Dermatology
    |December 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Topical application of delphinidin reduces psoriasiform lesions in the flaky skin mouse model by inducing epidermal differentiation and inhibiting inflammation.

    The British journal of dermatology·2014
    Same author

    Prognostic factors, prognostic indices and staging in mycosis fungoides and Sézary syndrome: where are we now?

    The British journal of dermatology·2014
    Same author

    The many molecular mysteries of melanoma.

    Methods in molecular medicine·2012
    Same author

    Polo-like kinase 1 (Plk1) in cutaneous T-cell lymphoma.

    The British journal of dermatology·2010
    Same author

    2-deoxyglucose sensitizes melanoma cells to TRAIL-induced apoptosis which is reduced by mannose.

    Biochemical and biophysical research communications·2010
    Same author

    Targeting glutamine metabolism sensitizes melanoma cells to TRAIL-induced death.

    Biochemical and biophysical research communications·2010
    Same journal

    Reducing plastic waste in skin-model research: Sustainable packaging as a practical first step.

    The Journal of investigative dermatology·2026
    Same journal

    Modern serum proteomics in precision medicine: Toward disease stratification and predictive, proactive treatment strategies.

    The Journal of investigative dermatology·2026
    Same journal

    An Integrated Skin Cell Atlas Decodes the Pilosebaceous Unit.

    The Journal of investigative dermatology·2026
    Same journal

    Residual CSB activity explains mild UV-sensitive syndrome phenotype caused by CSB mutations.

    The Journal of investigative dermatology·2026
    Same journal

    Charting a new melanoma risk factor: Satellite Naevus Prevalence in High-Risk and Population-Based Cohorts.

    The Journal of investigative dermatology·2026
    Same journal

    Human keratinocytes and fibroblasts coordinate early cutaneous innate defenses against Candida auris.

    The Journal of investigative dermatology·2026
    See all related articles

    Both Leu-8 positive and negative T cells are involved in allergic contact dermatitis, similar to in vitro studies. This research clarifies T cell subset roles in cell-mediated immunity in vivo.

    Area of Science:

    • Immunology
    • Dermatology

    Background:

    • Leu-8 is a T cell antigen with known in vitro functions.
    • Previous research suggests Leu-3+ T cells are crucial for cell-mediated immunity.

    Purpose of the Study:

    • To investigate the presence and roles of Leu-3+8+ and Leu-3+8- T cells in vivo during allergic contact dermatitis.
    • To analyze the expression of HLA-DR and HLA-DQ on keratinocytes in allergic contact dermatitis.

    Main Methods:

    • Immunohistological analysis of skin biopsies from patients with allergic contact dermatitis and Rhus dermatitis.
    • Immunophenotyping of T cell subsets (Leu-3+, Leu-8+) and other immune cells (Langerhans cells, B cells, NK cells).

    Main Results:

    • Both Leu-3+8+ and Leu-3+8- T cells were found in all studied biopsies.

    Related Experiment Videos

  • Leu-3+ T cells were the predominant T cell population; Langerhans cells increased over time.
  • HLA-DR+ keratinocytes were observed in a subset of biopsies, while HLA-DQ+ keratinocytes were absent.

    • Conclusions:

    • The findings indicate that both Leu-8+ and Leu-8- subsets of Leu-3+ T cells participate in in vivo cell-mediated immune responses in allergic contact dermatitis.
    • The study supports the in vitro findings regarding T cell subset involvement in cell-mediated immunity.
    • Keratinocyte expression of HLA-DR and HLA-DQ warrants further investigation in the context of allergic skin reactions.