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Thrombus Profiling Assay: A Microfluidics-Based Platform for Comprehensively Characterizing Biomechanical Thrombogenesis
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Evaluation of different sized blood sampling tubes for thromboelastometry, platelet function, and platelet count.

Jo Bønding Andreasen, Thea Unger Pistor-Riebold, Ingrid Hell Knudsen

    Clinical Chemistry and Laboratory Medicine
    |December 7, 2013
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    Smaller blood collection tubes (1.8 mL) are suitable for rotational thromboelastometry (RoTEM®) analyses, minimizing blood volume. However, tube size impacts platelet aggregation and count measurements, requiring specific tube sizes for accurate results.

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    Area of Science:

    • Hematology
    • Clinical Diagnostics
    • Laboratory Medicine

    Background:

    • Minimizing blood volume for diagnostic procedures is crucial, particularly in pediatric patients.
    • Investigating the impact of blood sample tube size on coagulation analyses is essential for optimizing diagnostic protocols.

    Purpose of the Study:

    • To determine if blood sampling tube size affects whole blood coagulation analyses, specifically rotational thromboelastometry (RoTEM®).
    • To assess the influence of different tube sizes on platelet aggregation and platelet count over time.

    Main Methods:

    • Rotational thromboelastometry (RoTEM®) analyses were performed on samples from 20 healthy individuals using 1.8, 2.7, and 3.6 mL tubes.
    • Platelet aggregation was analyzed using the Multiplate® Analyser with 3.6 mL and 1.8 mL tubes in 12 healthy individuals.
    • Platelet counts were measured at 10, 60, and 120 minutes post-collection for each tube size.

    Main Results:

    • No significant differences in RoTEM® measurements were observed across the different tube sizes (p=0.07-0.53).
    • Platelet aggregation was significantly lower in smaller tubes (1.8 mL) compared to larger tubes (p=0.0004).
    • Platelet counts remained stable in 3.6 mL tubes but decreased significantly in smaller tubes after 60 minutes (p<0.0001).

    Conclusions:

    • Blood sampling tube size does not impact RoTEM® analyses, supporting the use of 1.8 mL tubes to minimize blood draw volume.
    • Tube size significantly affects platelet aggregation and platelet count measurements, indicating that different sized tubes are not interchangeable for these assays.
    • For platelet count determination beyond 10 minutes post-collection in citrate anticoagulant tubes, a 3.6 mL tube is recommended to prevent falsely low values.