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A study on the inhibitory effect of matrine on gastric cancer SGC-7901 cells
Shimao Song1, Shengming Zhu, Zhiguo Zhang
1Department of Oncology, Taihe Hospital Affiliated of Hubei University of Medicine, Shiyan 442000, China.
Abstract:
The objective of this paper was to investigate the antitumour mechanism of action of matrine by studying its inhibitory effect on gastric cancer SGC-7901 cells. SGC-7901 cells were chosen, and cell-killing capacity of matrine on gastric cancer SGC-7901 cells was determined using MTT assay and single PI staining assay. The results showed that matrine had an inhibitory effect on gastric cancer SGC-7901 cells, which was somewhat dose-dependent. The study concluded that matrine has a significant in-vitro inhibitory effect on SGC-7901 tumour cells, influences cell cycle of SGC-7901 cells, and induces their apoptosis.
