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Related Concept Videos

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Crystallization is a phase transformation process in which crystals are precipitated from a supersaturated solution or formed from other sources. During crystallization, atoms or molecules arrange themselves into a well-defined, rigid crystal lattice to minimize energy.
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Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
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Growing Protein Crystals with Distinct Dimensions Using Automated Crystallization Coupled with In Situ Dynamic Light Scattering
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How spherical crystallization improves direct tableting properties: a review.

Maryam Maghsoodi1

  • 1Drug applied Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.

Advanced Pharmaceutical Bulletin
|December 7, 2013
PubMed
Summary
This summary is machine-generated.

Spherical crystallization improves drug particle properties for direct tableting. This particle design technique enhances flowability, packability, and compactability, making it ideal for efficient tablet manufacturing.

Keywords:
CompactabilityDirect tablettingFlowabilitySpherical crystallization

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Area of Science:

  • Pharmaceutical Sciences
  • Materials Science

Background:

  • Direct tableting offers cost and time savings over granulation.
  • Tablet quality relies heavily on the mechanical properties of drug crystals.
  • Inadequate particle properties necessitate granulation, adding complexity.

Purpose of the Study:

  • To review the application of spherical crystallization for improving direct tableting.
  • To highlight how spherical crystallization enhances critical micromeritic properties.

Main Methods:

  • Spherical crystallization as a particle design technique.
  • Simultaneous crystallization and agglomeration in a single step.
  • Assessment of improved micromeritic properties: flowability, packability, compactability.

Main Results:

  • Spherical crystallization effectively modifies particle characteristics.
  • Enhanced flowability, packability, and compactability are achieved.
  • Suitable particles for direct tableting are obtained.

Conclusions:

  • Spherical crystallization is a viable alternative to granulation for direct tableting.
  • This technique optimizes drug particles for improved tablet manufacturing.
  • It offers a streamlined approach to achieving desired tablet mechanical properties.