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Protective Role of GnRH Antagonist on Chemotherapy-induced Spermatogenesis Disorder: A Morphological Study

Daryosh Mohammadnejad1, Ali Abedelahi, Morteza Rashtbar

  • 1Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Advanced Pharmaceutical Bulletin
|December 7, 2013
PubMed
Abstract

Insights

This study shows that administering a GnRH antagonist before chemotherapy can protect male fertility. Cetrorelix prevented cisplatin-induced damage to sperm cells and germinal epithelium in mice.

Area of Science:

  • Reproductive biology
  • Oncology
  • Pharmacology

Background:

  • Anticancer drugs can impair male fertility by affecting spermatogenesis.
  • Protecting germinal epithelium is crucial for maintaining reproductive function during cancer treatment.

Purpose of the Study:

  • To investigate the protective effect of GnRH antagonist (cetrorelix) against anticancer drug-induced spermatogenic defects.
  • To evaluate the impact of cetrorelix on germinal epithelium health during chemotherapy.

Main Methods:

  • Adult male mice were divided into control, cisplatin-only, and cetrorelix-plus-cisplatin groups.
  • Cisplatin was administered to induce chemotherapy side effects, while cetrorelix was given preventively.
  • Testis tissues were analyzed using light and electron microscopy to assess cellular damage and protective effects.

Main Results:

  • Cisplatin treatment significantly reduced spermatogonial cells and germinal epithelium thickness.
  • Electron microscopy revealed cellular damage in cisplatin-treated mice, including mitochondrial vacuolation and organelle destruction.
  • Mice pretreated with cetrorelix showed normal testicular histology, similar to the control group.

Conclusions:

  • GnRH antagonist (cetrorelix) administration before cisplatin treatment effectively protected the germinal epithelium.
  • Cetrorelix shows potential as a protective agent against chemotherapy-induced male reproductive toxicity.
Keywords:
CetrorelixCispelatinTestisUltrastructure

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