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Related Concept Videos

Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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Stem Cell Therapy for Tissue Regeneration01:21

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Stem Cell Culture01:17

Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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iPS Cell Differentiation01:22

iPS Cell Differentiation

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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Adult Stem Cells01:33

Adult Stem Cells

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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Embryonic Stem Cells00:58

Embryonic Stem Cells

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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Isolation of Perivascular Multipotent Precursor Cell Populations from Human Cardiac Tissue
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Mesenchymal stem cells: new aspect in cell-based regenerative therapy.

Mozhdeh Mohammadian1, Karim Shamsasenjan, Parisa Lotfi Nezhad

  • 1Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

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Mesenchymal stem cells (MSCs) are promising for regenerative medicine due to their differentiation and immune-evasion capabilities. Platelet-rich products enhance MSC proliferation for therapeutic applications.

Keywords:
Autologous platelet rich productCell-based regenerative therapyMesenchymal stem cell

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Area of Science:

  • Regenerative Medicine
  • Cell Biology
  • Biotechnology

Background:

  • Mesenchymal stem cells (MSCs) are multipotent progenitors found in bone marrow.
  • MSCs support hematopoietic stem cells and can differentiate into various cell types.
  • They play a role in tissue repair and regeneration following injury.

Purpose of the Study:

  • To highlight the potential of MSCs in cell-based regenerative therapy.
  • To discuss the use of MSCs for treating bone defects, cardiovascular, and spinal cord injuries.
  • To explore methods for expanding MSCs for therapeutic implantation.

Main Methods:

  • Isolation of MSCs from human bone marrow or fat.
  • In vitro proliferation and differentiation studies.
  • Evaluation of MSCs' potential for immune rejection escape.

Main Results:

  • MSCs demonstrate multipotency and regenerative capabilities in vitro and in vivo.
  • Their ability to evade immune rejection makes them suitable for cell replacement therapy.
  • Platelet-rich products can replace FBS in culture media to enhance MSC proliferation.

Conclusions:

  • MSCs offer significant promise for regenerative therapies targeting various injuries and defects.
  • Optimizing MSC expansion using growth factors from platelet-rich products is crucial for clinical applications.
  • Further research into MSC-based therapies could revolutionize tissue regeneration.