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Persistent erythema multiforme associated with Epstein-Barr virus infection
N Turnbull1, D Hawkins, M Atkins
1Department of Dermatology, Chelsea and Westminster Hospital, London, UK.
Abstract:
Erythema multiforme (EM) is a common, self-limiting condition. Recurrent EM is a well-recognised variant, often associated with herpes simplex virus infection. It is frequently managed with prophylactic aciclovir. Anecdotal reports suggest that recurrent EM may be associated with the use of corticosteroids. Persistent EM, however, is a rare variant, with few cases reported in the literature. It has a protracted course often with atypical and inflammatory lesions. It has been associated with occult viral infections, particularly Epstein-Barr Virus (EBV), as well as inflammatory bowel disease and malignancy. We report a case of EM associated with EBV infection.
Insights
Erythema multiforme (EM) is a common skin condition. This study highlights a rare persistent form of EM linked to Epstein-Barr Virus (EBV) infection.
Area of Science:
- Dermatology
- Virology
- Immunology
Background:
- Erythema multiforme (EM) is typically self-limiting, with recurrent forms often linked to herpes simplex virus.
- Persistent EM is rare, characterized by prolonged, atypical inflammatory lesions.
- Potential associations include viral infections, inflammatory bowel disease, and malignancy.
Observation:
- This case report details a patient with persistent Erythema multiforme.
- The persistent EM was found to be associated with Epstein-Barr Virus (EBV) infection.
- This association is less common than typical EM triggers.
Findings:
- Persistent Erythema multiforme can be associated with Epstein-Barr Virus (EBV).
- This case adds to the limited literature on persistent EM and its potential triggers.
- The protracted and atypical nature of persistent EM warrants further investigation into underlying causes.
Implications:
- Understanding the link between EBV and persistent EM may guide diagnostic approaches.
- This finding could inform management strategies for rare, persistent EM cases.
- Further research is needed to elucidate the mechanisms linking EBV to persistent EM.
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