Core-shell nanocarriers for cancer therapy. Part I: biologically oriented design rules

Area of Science:

• Nanomedicine
• Oncology
• Materials Science

Background:

• Nanotechnology provides advanced therapeutic, imaging, and diagnostic approaches in cancer treatment.
• Core-shell nanocarriers are engineered to overcome biological barriers that limit conventional chemotherapy effectiveness.

Purpose of the Study:

• To summarize nanocarrier design principles based on biological requirements.
• To highlight alternative administration routes for nanocarrier-based cancer therapy.

Main Methods:

• Review of nanocarrier design rules dictated by biological requirements.
• Exploration of non-intravenous administration routes for nanoncologicals.

Main Results:

• Nanocarrier engineering can address limitations of conventional chemotherapy.
• Alternative administration routes offer potential for localized chemotherapy delivery.

Conclusions:

• While intravenous injection is common, alternative routes may revolutionize cancer treatment.
• Further research on nanoconstruct stability and interactions is crucial for clinical translation.