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Published on: April 23, 2018
SHIP2: a "new" insulin pathway target for aging research.
Giulia Accardi1, Claudia Virruso, Carmela Rita Balistreri
11 Immunosenescence Unit, Department of Pathobiology and Medical and Forensic Biotechnologies, University of Palermo , Palermo, Italy .
A specific gene variant (rs144989913) in SHIP2 may be linked to aging processes, not age-related diseases like Alzheimer's or type 2 diabetes. This finding relates to SHIP2's role in insulin signaling and aging.
Area of Science:
- Genetics and Aging Research
- Metabolic and Neurological Disorders
Background:
- Systemic inflammation and central adiposity are key drivers of metabolic syndrome.
- Metabolic syndrome, type 2 diabetes mellitus (T2DM), cardiovascular disease, and Alzheimer's disease (AD) share a common inflammatory basis.
- Abnormalities in insulin and IGF signaling in AD brains suggest it may represent a form of diabetes.
Purpose of the Study:
- To investigate the association of single-nucleotide polymorphisms (SNPs) in the SHIP2 gene with aging and age-related diseases.
- To explore the role of SHIP2, a negative regulator of insulin signaling, in the context of Alzheimer's disease and T2DM.
Main Methods:
- A case-control study was conducted.
- Subjects included AD and T2DM patients as cases, and young, old, and centenarian individuals as controls.
- The study analyzed the rs144989913 SNP within the SHIP2 gene.
Main Results:
- A potential correlation was identified between the rs144989913 SNP and the aging process itself, irrespective of successful or unsuccessful aging.
- This SNP involves a 28 bp insertion/deletion, potentially affecting SHIP2 expression.
- No direct association was found between this SNP and age-related diseases like AD or T2DM.
Conclusions:
- The rs144989913 SNP in the SHIP2 gene is tentatively associated with aging, not specific age-related diseases.
- SHIP2's role as a negative regulator of insulin signaling may link its association with aging to the insulin/IGF-1 pathway, which is implicated in longevity.
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