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Impaired emotional state, quality of life and cognitive functions in young hypogonadal men

L Lašaitė1, J Ceponis, R T Preikša

  • 1Institute of Endocrinology, Lithuanian University of Health Sciences, Kaunas, Lithuania.

Andrologia
|December 10, 2013
PubMed

Insights

Young men with hypogonadism experience poorer emotional well-being and quality of life. Cognitive functions are significantly impaired in hypogonadal males compared to healthy controls.

Area of Science:

  • Endocrinology
  • Psychology
  • Neuroscience

Background:

  • Hypogonadism, a condition of deficient testosterone production, affects men's health.
  • The impact of hypogonadism on emotional state, quality of life, and cognitive function in young men requires further investigation.

Purpose of the Study:

  • To analyze the emotional state, quality of life, and cognitive functions in young men with hypogonadism.
  • To compare these parameters between hypogonadal men and age-matched healthy controls.

Main Methods:

  • Thirty-four young hypogonadal males and 34 age-matched healthy males were recruited.
  • Emotional state was assessed using the Profile of Mood States.
  • Quality of life was evaluated using the WHO Brief Quality of Life Questionnaire.
  • Cognitive functioning was assessed using the Trail Making Test and Wechsler Adult Intelligence Scale's Digit Span Test.

Main Results:

  • Hypogonadal men exhibited higher levels of depression, fatigue, and confusion, and lower vigor compared to controls.
  • Psychological and social domains of quality of life were significantly worse in hypogonadal men.
  • Cognitive functions, including executive function, attention, visual scanning, and psychomotor speed, were significantly impaired in hypogonadal men.
  • Testosterone levels correlated with psychological quality of life, and FT4 concentration related to cognitive functioning.

Conclusions:

  • Young hypogonadal patients demonstrate impaired emotional state and reduced quality of life.
  • Cognitive functioning is most severely affected in young men with hypogonadism.
  • These findings highlight the broad impact of hypogonadism beyond physical symptoms.

Keywords:
Cognitive functionsemotional statequality of lifeyoung hypogonadal men

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