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Cardiac and proinflammatory markers predict prognosis in cirrhosis

Signe Wiese1, Christian Mortensen, Jens P Gøtze

  • 1Department of Clinical Physiology and Nuclear Medicine, Center of Functional and Diagnostic Imaging and Research, Copenhagen, Denmark; Gastro Unit, Medical Department, Hvidovre Hospital, Hvidovre, Denmark.

Liver International : Official Journal of the International Association for the Study of the Liver
|December 10, 2013
PubMed

Insights

Cardiac and inflammatory markers, including high-sensitivity troponin T (hs-TnT) and soluble urokinase-type plasminogen activator receptor (suPAR), are linked to cirrhosis severity and patient survival. hs-TnT and suPAR show prognostic value in managing liver disease complications.

Area of Science:

  • Hepatology
  • Cardiology
  • Biomarker Research

Background:

  • Inflammation and cardiac dysfunction are key factors in cirrhosis complications and mortality.
  • Novel cardiac markers (proANP, copeptin, hs-TnT) and inflammatory markers (suPAR, hs-CRP) are implicated.

Purpose of the Study:

  • To investigate the relationship between cardiac and inflammatory markers with liver disease severity.
  • To assess associations with cardiac and hemodynamic changes.
  • To determine the impact on long-term survival in cirrhotic patients.

Main Methods:

  • 193 stable cirrhotic patients (Child classes A, B, C) underwent full hemodynamic assessment.
  • Circulating levels of proBNP, proANP, copeptin, hs-TnT, LBP, IL-6, IL-8, IP-10, VEGF, hs-CRP, and suPAR were measured.

Main Results:

  • suPAR, hs-CRP, and hs-TnT levels differed significantly across Child classes.
  • ProANP and suPAR correlated with hepatic venous pressure gradient and systemic vascular resistance.
  • hs-TnT, ascites, and hepatic venous pressure gradient were the strongest predictors of mortality in multivariate analysis.

Conclusions:

  • Cardiac and inflammatory markers correlate with cirrhosis severity, portal hypertension, and survival.
  • hs-TnT and suPAR demonstrate significant prognostic information for cirrhotic patients.
Abstract

Keywords:
chronic liver diseasecirrhotic cardiomyopathyinflammationportal hypertension

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