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Related Experiment Video

Updated: May 5, 2026

Hand-held Clinical Photoacoustic Imaging System for Real-time Non-invasive Small Animal Imaging
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Small-animal research imaging devices.

Eugene J Fine1, Lawrence Herbst, Linda A Jelicks

  • 1Department of Radiology, Albert Einstein College of Medicine, Montefiore Medical Center, Nuclear Medicine Division, Bronx, NY.

Seminars in Nuclear Medicine
|December 10, 2013
PubMed
Summary
This summary is machine-generated.

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Advanced animal imaging, particularly in rodents, aids human molecular biology research. Genetically engineered mice (GEM) offer disease models, with potential for veterinary applications, utilizing techniques like CT, PET, and MRI.

Area of Science:

  • Veterinary Medicine
  • Biomedical Imaging
  • Animal Models

Background:

  • Modern animal studies and advanced imaging techniques have developed over the last century and few decades, respectively.
  • In vivo imaging is increasingly vital in scientific research.
  • Small animal imaging, especially using rodents like genetically engineered mice (GEM), is crucial for understanding human molecular biology and disease.

Purpose of the Study:

  • To highlight the utility of in vivo imaging in scientific research.
  • To discuss the application of genetically engineered mice (GEM) in modeling human diseases.
  • To explore the potential of GEM for veterinary research.

Main Methods:

  • Utilizing small animal imaging techniques such as CT, PET, SPECT, MRI, and optical imaging.

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  • Employing genetically engineered mice (GEM) that spontaneously develop diseases mimicking human conditions.
  • Comparing the advancement of GEM for human research versus veterinary research.

    • Main Results:

    • Small animal imaging, particularly with GEM, has been instrumental in advancing human molecular biology and pathophysiology research.
    • While GEM models for veterinary diseases exist, their development has generally lagged behind human research.
    • GEM offer potential for developing spontaneous disease models relevant to veterinary medicine.

    Conclusions:

    • In vivo small animal imaging is a powerful tool in biomedical research.
    • Genetically engineered mice (GEM) serve as valuable models for human diseases and hold promise for veterinary research.
    • Continued development of GEM models could significantly benefit veterinary science.