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Related Experiment Videos

[Microcirculation in white atrophy].

J F Merlen, J M Goget

    Phlebologie
    |July 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Raynaud phenomenon and white atrophy involve microcirculation issues. Research suggests a "histoangiopathy" of the pericapillary sheath, not infarcts or vasculitis, is the underlying cause.

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    Area of Science:

    • Dermatology
    • Vascular Biology
    • Histopathology

    Context:

    • Critiques of Raynaud phenomenon and Milian's white atrophy persist.
    • Previous studies inadequately defined these conditions, focusing narrowly on microcirculation.
    • Direct capillaroscopy, functional tests, and biopsies showed limitations in diagnosing these phenomena.

    Purpose:

    • To re-evaluate the underlying pathology of Raynaud phenomenon and Milian's white atrophy.
    • To challenge the conventional understanding of these conditions as solely microcirculatory disorders.
    • To propose an alternative etiological framework based on observed histological changes.

    Summary:

    • Capillaroscopy reveals cicatrization, "capillary" neogenesis, and histogenic disorders, including avascular zones and abnormal capillary loops.

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  • Neocapillaries suggest immature vascular elements and issues with venous stasis hydraulics.
  • Capillary permeability disorders are linked to neovascularization, but criteria for "cutaneous infarctus" or "vascularitis" are absent.

    • Impact:

    • This study reinterprets Raynaud phenomenon and white atrophy as a "histoangiopathy" involving pericapillary sheath and interstitial connective tissue deterioration.
    • The findings suggest anomalies akin to plastic polymer degradation within the endarterial bloc.
    • Leukocyte trapping in dependent areas is identified as a potential contributing factor to the observed pathology.