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Related Concept Videos

The Micturition Reflex01:26

The Micturition Reflex

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Urination, or micturition involves the coordination of the bladder's detrusor muscle and two sphincters to ensure controlled bladder emptying.
The process begins with bladder filling, where the bladder wall stretches as urine accumulates. This stretching activates the urine storage reflex, mediated by the sacral spinal segments and the pontine storage center. Efferent sympathetic impulses stimulate the detrusor muscle to relax and the internal urethral sphincter to contract, facilitating...
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Related Experiment Video

Updated: May 5, 2026

Urinary Bladder Distention Evoked Visceromotor Responses as a Model for Bladder Pain in Mice
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Neuromodulation attenuates bladder hyperactivity in a rat cystitis model.

Xin Su1, Angela Nickles, Dwight E Nelson

  • 1Medtronic, Inc, Neuromodulation Research, 7000 Central Avenue, Minneapolis, MN 55432, USA. xin.su@medtronic.com.

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Summary
This summary is machine-generated.

Electrical stimulation of the L6 spinal nerve (SN) effectively reversed bladder hyperactivity caused by acetic acid. This therapy shows promise for treating overactive bladder conditions.

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Area of Science:

  • Neuroscience
  • Urology
  • Physiology

Background:

  • Investigated electrical stimulation of the L6 spinal nerve (SN) for urinary bladder function regulation.
  • Utilized cystometry in normal rats and rats with acetic acid-induced cystitis.

Purpose of the Study:

  • To evaluate the efficacy of L6 SN electrical stimulation in modulating bladder activity.
  • To assess the therapeutic potential for overactive bladder (OAB) conditions.

Main Methods:

  • Continuous flow cystometry was performed in anesthetized rats.
  • Measured threshold pressure, basal pressure, inter-contraction interval, and voided volume.
  • Electrical stimulation of the L6 SN was applied bilaterally.

Main Results:

  • Acetic acid induced bladder hyperactivity, decreasing threshold pressure, inter-contraction interval, and voided volume.
  • Bilateral L6 SN stimulation significantly reversed these effects in both normal and acetic acid-treated rats.
  • SN stimulation increased inter-contraction interval and voided volume, with slightly greater effects in acetic acid-treated rats, though not statistically significant.

Conclusions:

  • L6 SN stimulation effectively regulates micturition, consistent with therapeutic outcomes for overactive bladder.
  • Findings support the potential of SN stimulation as a treatment for bladder dysfunction.
  • The study provides evidence for the neuromodulatory effects of SN stimulation on bladder function.