Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 4, 2026

Technical Demonstration of Whole Genome Array Comparative Genomic Hybridization
16:37

Technical Demonstration of Whole Genome Array Comparative Genomic Hybridization

Published on: August 6, 2008

12.5K

[Anaplastic large cell lymphoma: an array-based comparative genomic hybridization study].

Miao Wang1, Ran Liu, Li-ya Su

  • 1Department of Pathology, Capital Medical University, Beijing 100069, China.

Zhonghua Bing Li Xue Za Zhi = Chinese Journal of Pathology
|December 10, 2013
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Profiling and functional analysis of exosomal circRNAs from EBV-associated gastric carcinoma CSCs.

Journal of cancer research and clinical oncology·2026
Same author

Development and validation of a nomogram comprising GLUT1 and clinical characteristics for predicting overall survival in intrahepatic cholangiocarcinoma.

Translational cancer research·2025
Same author

Efficacy and safety of fire needle therapy for plaque psoriasis: a randomized, single-blind, multicenter clinical trial.

QJM : monthly journal of the Association of Physicians·2025
Same author

Occurrence, dissemination, and inactivation technologies of pathogens in the process of common solid waste treatment and disposal.

Ying yong sheng tai xue bao = The journal of applied ecology·2025
Same author

Predictive value of clinical syntax score for clinical outcomes on patients with acute coronary syndrome undergoing rotational atherectomy.

BMC cardiovascular disorders·2025
Same author

The biological macromolecules constructed Matrigel for cultured organoids in biomedical and tissue engineering.

Colloids and surfaces. B, Biointerfaces·2024
Same journal

[The application of single-cell omics and spatial omics in investigating tumor microenvironment heterogeneity of non-small cell lung cancer].

Zhonghua bing li xue za zhi = Chinese journal of pathology·2026
Same journal

[Value of p53 immunohistochemistry in diagnosing esophageal squamous intraepithelial neoplasia].

Zhonghua bing li xue za zhi = Chinese journal of pathology·2026
Same journal

[Pulmonary immunoglobulin-storing histiocytosis: report of a case].

Zhonghua bing li xue za zhi = Chinese journal of pathology·2026
Same journal

[Multiple recurrences with orbital invasion arising from primary sinonasal solitary fibrous tumor: report of a case].

Zhonghua bing li xue za zhi = Chinese journal of pathology·2026
Same journal

[Primary choriocarcinoma of the liver metastasizes to the gallbladder and gallbladder adenosquamous cell carcinoma with enteroblastic differentiation: report of a case].

Zhonghua bing li xue za zhi = Chinese journal of pathology·2026
Same journal

[GLI1 rearrangement in colon tumor: report of a case].

Zhonghua bing li xue za zhi = Chinese journal of pathology·2026
See all related articles

Array-based comparative genomic hybridization (aCGH) revealed widespread genetic alterations in anaplastic large cell lymphoma (ALCL). Specific chromosomal gains in ALCL differ between ALK-positive and ALK-negative subtypes, suggesting distinct disease pathways.

Area of Science:

  • Oncology
  • Genetics
  • Molecular Biology

Background:

  • Anaplastic large cell lymphoma (ALCL) is a distinct subtype of non-Hodgkin lymphoma.
  • Understanding the genomic landscape of ALCL is crucial for elucidating its pathogenesis and identifying therapeutic targets.

Purpose of the Study:

  • To investigate the genome-wide molecular cytogenetic abnormalities in ALCL using array-based comparative genomic hybridization (aCGH).
  • To correlate chromosomal alterations with anaplastic lymphoma kinase (ALK) protein expression status.

Main Methods:

  • Analyzed 25 ALCL cases using immunohistochemistry for ALK expression and fluorescence in situ hybridization for genetic abnormalities.
  • Employed aCGH to detect chromosomal gains and losses across the genome.
  • Correlated aCGH findings with ALK status.

More Related Videos

Array Comparative Genomic Hybridization Array CGH for Detection of Genomic Copy Number Variants
09:16

Array Comparative Genomic Hybridization Array CGH for Detection of Genomic Copy Number Variants

Published on: February 21, 2015

19.4K
Comparative Lesions Analysis Through a Targeted Sequencing Approach
08:16

Comparative Lesions Analysis Through a Targeted Sequencing Approach

Published on: November 5, 2019

6.2K

Related Experiment Videos

Last Updated: May 4, 2026

Technical Demonstration of Whole Genome Array Comparative Genomic Hybridization
16:37

Technical Demonstration of Whole Genome Array Comparative Genomic Hybridization

Published on: August 6, 2008

12.5K
Array Comparative Genomic Hybridization Array CGH for Detection of Genomic Copy Number Variants
09:16

Array Comparative Genomic Hybridization Array CGH for Detection of Genomic Copy Number Variants

Published on: February 21, 2015

19.4K
Comparative Lesions Analysis Through a Targeted Sequencing Approach
08:16

Comparative Lesions Analysis Through a Targeted Sequencing Approach

Published on: November 5, 2019

6.2K

Main Results:

  • All 25 ALCL cases exhibited chromosomal alterations, with gains being more frequent than losses.
  • Frequent chromosomal gains were observed at 5p13.2, 3q21.1, 2q21.3, 3p25.1, 14q32.33, and 17q21.2.
  • Significant differences in gains at 2q21.3, 6p22.1, and 3p25.1 were found between ALK-positive and ALK-negative ALCL subgroups (P < 0.05).

Conclusions:

  • aCGH is effective in identifying complex molecular genetic variations in ALCL.
  • Distinct chromosomal gain patterns in ALK-positive and ALK-negative ALCL suggest divergent pathogenetic mechanisms involving different signaling pathways.