[Combined therapy with high-dosage cisplatin and radiation in advanced ENT tumors (a phase-II study)]

The most promising method to obtain at least a palliative effect in advanced ORL tumors seems to be a combination of chemotherapy and radiotherapy. We made an attempt to reach a higher remission rate (n = 28) by means of an extraordinary high dose of cis-platinum and the usual maximum radiation dose of 60 Gy: The method had to be abandoned because the rates of success (CR and PR) decreased from 79% to 46% in eight months, the side effects, however, were beyond a tolerable degree. We are of the opinion that the same results can be obtained by less radical methods, too.