Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Molecular Models

Molecular Models

Physical models representing molecular architectures of chemical compounds play essential roles in understanding chemistry. The use of molecular models makes it easier to visualize the structures and shapes of atoms and molecules.

Noncovalent Attractions in Biomolecules

Noncovalent Attractions in Biomolecules

Noncovalent attractions are associations within and between molecules that influence the shape and structural stability of complexes. These interactions differ from covalent bonding in that they do not involve sharing of electrons.
Four types of noncovalent interactions are hydrogen bonds, van der Waals forces, ionic bonds, and hydrophobic interactions.
Hydrogen bonding results from the electrostatic attraction of a hydrogen atom covalently bonded to a strong-electronegative atom like oxygen,...

Noncovalent Attractions in Biomolecules

Noncovalent Attractions in Biomolecules

Protein Organization

Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence....

Protein Organization

Protein Organization

Protein Folding

Protein Folding

Proteins are chains of amino acids linked together by peptide bonds. Upon synthesis, a protein folds into a three-dimensional conformation, critical to its biological function. Interactions between its constituent amino acids guide protein folding, and hence the protein structure is primarily dependent on its amino acid sequence.
Protein Structure Is Critical to Its Biological Function
Proteins perform a wide range of biological functions such as catalyzing chemical reactions, providing...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Polycyclic Aromatic Hydrocarbons: Solvation, Solubility, and Hydrophobic Effects from Monte Carlo Simulations.

The journal of physical chemistry. B·2025

Same author

Mechanistic basis for a novel dual-function Gag-Pol dimerizer potentiating CARD8 inflammasome activation and clearance of HIV-infected cells.

NPJ drug discovery·2025

Same author

Free Energies of Solvation in Benzene and Hexafluorobenzene: Is Explicit Polarization Needed?

The journal of physical chemistry. B·2025

Same author

The need to implement FAIR principles in biomolecular simulations.

Nature methods·2025

Same author

Exploring Possible Drug-Resistant Variants of SARS-CoV-2 Main Protease (M<sup>pro</sup>) with Noncovalent Preclinical Candidate, Mpro61.

ACS bio & med chem Au·2025

Same author

Prodrug nanotherapy demonstrates <i>in vivo</i> anticryptosporidial efficacy in a mouse model of chronic <i>Cryptosporidium</i> infection.

RSC pharmaceutics·2024

Search research articles

Related Experiment Video

Updated: May 5, 2026

Modeling an Enzyme Active Site using Molecular Visualization Freeware

Modeling an Enzyme Active Site using Molecular Visualization Freeware

Published on: December 25, 2021

Foundations of biomolecular modeling.

William L Jorgensen¹

¹Department of Chemistry, Yale University, New Haven, CT 06520, USA.

|December 10, 2013

Summary

The 2013 Nobel Prize in Chemistry honored multiscale models for complex chemical systems. This foundational work from the 1970s enables today's advanced biomolecular and organic system modeling.

Area of Science:

Computational Chemistry
Molecular Modeling
Biophysics

Background:

The 2013 Nobel Prize in Chemistry recognized the pioneering development of multiscale models.
This work, originating in the 1970s, addressed the challenge of simulating complex chemical systems.

Discussion:

Multiscale models bridge the gap between quantum mechanics and classical mechanics.
They enable the study of large and intricate systems, such as proteins and enzymes.
The honored research laid the groundwork for modern computational chemistry approaches.

Key Insights:

Development of hybrid quantum mechanics/molecular mechanics (QM/MM) methods.
Application of these models to understand reaction mechanisms and molecular dynamics.
Significant advancements in predicting chemical behavior and biological processes.

More Related Videos

3D Printing of Biomolecular Models for Research and Pedagogy

3D Printing of Biomolecular Models for Research and Pedagogy

Published on: March 13, 2017

Structure-Based Simulation and Sampling of Transcription Factor Protein Movements along DNA from Atomic-Scale Stepping to Coarse-Grained Diffusion

Structure-Based Simulation and Sampling of Transcription Factor Protein Movements along DNA from Atomic-Scale Stepping to Coarse-Grained Diffusion

Published on: March 1, 2022

Related Experiment Videos

Last Updated: May 5, 2026

Modeling an Enzyme Active Site using Molecular Visualization Freeware

Modeling an Enzyme Active Site using Molecular Visualization Freeware

Published on: December 25, 2021

3D Printing of Biomolecular Models for Research and Pedagogy

3D Printing of Biomolecular Models for Research and Pedagogy

Published on: March 13, 2017

Structure-Based Simulation and Sampling of Transcription Factor Protein Movements along DNA from Atomic-Scale Stepping to Coarse-Grained Diffusion

Structure-Based Simulation and Sampling of Transcription Factor Protein Movements along DNA from Atomic-Scale Stepping to Coarse-Grained Diffusion

Published on: March 1, 2022

Outlook:

Continued refinement and application of multiscale modeling in drug discovery and materials science.
Integration with experimental techniques for a more comprehensive understanding of chemical systems.
Future potential in predicting complex biological functions and designing novel molecules.