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Updated: May 5, 2026
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Determining the Functional Status of the Corticospinal Tract Within One Week of Stroke
Published on: February 22, 2020
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Corticomuscular coherence in acute and chronic stroke.
Katherina von Carlowitz-Ghori1, Zubeyir Bayraktaroglu2, Friederike U Hohlefeld3
1Neurophysics Group, Department of Neurology, Charité - University Medicine Berlin, Germany; Institute of Science and Ethics, University of Bonn, Germany; Department of Software Engineering and Theoretical Computer Science, Berlin Institute of Technology, Berlin, Germany.
Summary
Corticomuscular coherence (CMC) changes dynamically after stroke, with altered amplitude and frequency in the acute phase that normalize by the chronic stage. These shifts may reflect the brain
Area of Science:
- Neuroscience
- Rehabilitation Medicine
- Biomedical Engineering
Background:
- Motor recovery post-stroke involves neuronal plasticity, but not all neural changes correlate with functional motor improvement.
- Corticomuscular coherence (CMC) quantifies neural reorganizations relevant to motor recovery.
Purpose of the Study:
- To investigate dynamic changes in CMC during both acute and chronic stroke recovery stages.
- To compare CMC in stroke patients with healthy controls.
Main Methods:
- Utilized multichannel electroencephalography (EEG) and electromyography (EMG) recordings.
- Employed an optimization algorithm to detect corticomuscular interactions.
Main Results:
- Acute stroke showed higher CMC amplitude on the unaffected side and decreased peak frequencies on both sides compared to chronic stages and controls.
- No significant inter-hemispheric or group differences in CMC were observed in the chronic stage.
Conclusions:
- Acute CMC alterations may stem from transiently reduced inhibition, normalizing during recovery.
- Modulation of CMC parameters over time likely indicates the motor recovery process.
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