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Spatial memory extinction: a c-Fos protein mapping study.

M Méndez-Couz¹, N M Conejo¹, G Vallejo²

¹Laboratory of Neuroscience, Department of Psychology, Instituto de Neurociencias del Principado de Asturias (INEUROPA), University of Oviedo, Plaza Feijóo s/n, 33003 Oviedo, Spain.

Behavioural Brain Research

|December 10, 2013

Summary

This summary is machine-generated.

This study investigated brain regions involved in forgetting spatial memories. The medial prefrontal cortex, amygdala, and lateral mammillary nuclei are crucial for spatial memory extinction.

Keywords:

ANOVA Ba CA1d CA1v CA3d CA3v CG CS Ce DGd DGv EX EXR Extinction FWE IEGs IL LM MM MWM Mammillary body Me Morris water maze N PBS PBS solution containing triton PBS-T PL Prefrontal cortex RSA RSG Rat Spatial memory US amygdala basal nucleus amygdala central nucleus amygdala medial nucleus analysis of variance c-Fos cingulate cortex conditioned stimulus control naïve group cornu ammonis 1 of the dorsal hippocampus cornu ammonis 1 of the ventral hippocampus cornu ammonis 3 of the dorsal hippocampus cornu ammonis 3 of the ventral hippocampus degrees of freedom dentate gyrus of the dorsal hippocampus dentate gyrus of the ventral hippocampus df extinction group extinction plus retention probe group familywise error rate immediate early expression gene infralimbic cortex mammillary bodies lateral nucleus mammillary bodies medial nucleus phosphate-buffered saline prelimbic cortex retrosplenial agranular cortex retrosplenial granular cortex unconditioned stimulus

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Area of Science:

Neuroscience
Cognitive Neuroscience
Behavioral Neuroscience

Background:

The neural mechanisms of spatial memory consolidation are well-understood.
However, the brain structures involved in the extinction of spatial memories are largely unknown.

Purpose of the Study:

To investigate the functional role of specific brain regions during the extinction of a learned spatial memory task.
To identify the neural substrates underlying the forgetting of spatial information.

Main Methods:

Adult male Wistar rats were trained in the Morris water maze, a spatial reference memory task.
Changes in c-Fos immunoreactivity were assessed in cortical and subcortical regions post-training and during extinction.
The hidden platform was removed to induce extinction, and spontaneous recovery was tested 24 hours later.

Main Results:

Extinction of the escape behavior occurred within 16 trials without spontaneous recovery.
Significantly increased c-Fos expression was observed in the amygdala and medial prefrontal cortex during extinction.
The lateral mammillary bodies also showed elevated c-Fos positive cells compared to controls.

Conclusions:

The medial prefrontal cortex and amygdala complex are implicated in the extinction of spatial memories.
Diencephalic structures, specifically the lateral mammillary nuclei, play a role in this process.
These findings highlight the involvement of specific brain circuits in forgetting spatial information, contrasting with classical conditioning studies.