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Aging and immunity - impact of behavioral intervention
Ludmila Müller1, Graham Pawelec2
1Max Planck Institute for Human Development, Lentzeallee 94, D-14195 Berlin, Germany.
Brain, Behavior, and Immunity
|December 10, 2013
Summary
Elderly immune responses are less effective against new pathogens but may amplify responses to familiar ones due to changes in immune cell populations and intrinsic aging processes.
Area of Science:
- Immunology
- Gerontology
Background:
- Immune responses decline with age, impacting efficacy against novel pathogens.
- Age-related changes include reduced naive immune cells and increased memory cells.
Purpose of the Study:
- To outline immune differences between younger and older individuals.
- To discuss the impact of behavioral variations on immunosenescence.
Main Methods:
- Review of existing studies on immune cell populations in different age groups.
- Analysis of intrinsic and extrinsic factors influencing immune aging.
Main Results:
- Elderly exhibit diminished responses to new pathogens but amplified responses to previously encountered ones.
- Age-associated changes in hematopoietic stem cells and thymic involution affect T cell production.
- Innate immune cells may increase in number but decrease in per-cell efficacy.
Conclusions:
- Immunosenescence results from both chronological age and life course environmental interactions.
- Factors like microbiome, nutrition, exercise, and stress significantly modulate immune aging.
Keywords:
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