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GpIbα interacts exclusively with exosite II of thrombin

Bernhard C Lechtenberg1, Stefan M V Freund2, James A Huntington1

  • 1Department of Haematology, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Hills Road, Cambridge CB2 0XY, United Kingdom.

Journal of Molecular Biology
|December 10, 2013
PubMed
Summary

Platelet activation by thrombin is key in hemostasis. Thrombin binds to glycoprotein Ibα (GpIbα) via exosite II, recruiting it to the platelet surface for PAR-1 activation.

Keywords:
GpIbαLRRNMRPARPEGPPACKSPRTMTROSYcrystallographyd-phenylalanyl-l-prolyl-l-arginine chloromethyl ketoneexositeglycoprotein Ibαhaemostasisleucine-rich repeatplateletpolyethylene glycolprotease-activated receptorsurface plasmon resonancethrombomodulintransverse relaxation optimised spectroscopy

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