Aggregated chromosomes transfer in human oocytes
Related Experiment Video
Updated: May 5, 2026

Chromatin Spread Preparations for the Analysis of Mouse Oocyte Progression from Prophase to Metaphase II
Published on: February 26, 2018
Junko Otsuki1, Yasushi Nagai1, Tadashi Sankai2
1Nagai Clinic, 607-1 Kamihikona, Misato, Saitama 341-0004, Japan.
Abstract:
Germinal-vesicle (GV) transfer, spindle-chromosome complex transfer in metaphase-II oocytes and two pronuclei transfer have been evaluated as possible treatments for patients who have mitochondrial diseases. However, GV transfers often lead to heteroplasmy while the other two methods are frequently associated with aneuploidy. The present study used a new method based on the transfer of aggregated chromosomes, which occurs in human oocytes, before the metaphase spindle is established.
Related Concept Videos
Oogenesis
Oogenesis
Each primary oocyte is surrounded by a layer of pre-granulosa cells, forming what is...
Crossing Over
The homologous pairs of sister chromosomes—one from the maternal and one from the paternal genome—then begin to align alongside each other lengthwise, matching corresponding DNA positions in a process...
Crossing Over
What is Meiosis?
What is Meiosis?
Although meiosis shares similarities with mitosis—both rely on microtubules...

