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The 2014 Nucleic Acids Research Database Issue and an updated NAR online Molecular Biology Database Collection.

Xosé M Fernández-Suárez1, Daniel J Rigden, Michael Y Galperin

  • 1Life Technologies, Inchinnan Business Park, Paisley PA4 9RF, UK, Institute of Integrative Biology, University of Liverpool, Crown Street, Liverpool L69 7ZB, UK and National Center for Biotechnology Information (NCBI), National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA.

Nucleic Acids Research
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Summary

The 2014 Nucleic Acids Research Database Issue features 58 new and 123 updated molecular biology databases, enhancing access to critical biological data and research tools.

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Area of Science:

  • Molecular Biology
  • Bioinformatics
  • Genomics

Background:

  • The 2014 Nucleic Acids Research (NAR) Database Issue presents a comprehensive overview of molecular biology databases.
  • This issue categorizes databases into eight major subject areas for improved user navigation.
  • It includes descriptions of 58 novel databases and updates for 123 existing ones.

Discussion:

  • Highlights include databases for transcription factor binding sites, structural biology, and bacterial taxonomy.
  • Popular databases such as CAZy, DGV, dbGaP, DrugBank, KEGG, miRBase, Pfam, Reactome, SEED, TCDB, and UniProt have received updates.
  • Significant developments in protein structure classification are presented with SCOPe and SCOP2.

Key Insights:

  • The issue introduces new resources like RNA Bricks and updates on structural databases (PDBe, PDBsum, ArchDB, Gene3D, ModBase, Nucleic Acid Database, iPfam).
  • NCBI's MMDB is updated with VAST+ for enhanced protein structure comparison.
  • Metagenomics and bacterial taxonomy are covered with updates to LPSN, RDP, and Silva/LTP.

Outlook:

  • The NAR online Molecular Biology Database Collection now comprises 1552 databases.
  • This issue serves as a vital resource for researchers in molecular biology, genomics, and structural biology.
  • All content is freely accessible online via the Nucleic Acids Research website.