Related Experiment Video
Updated: May 5, 2026
18:48
In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
Published on: August 12, 2017
13.8K
Innate immune cells in transplantation.
Jessica H Spahn1, Wenjun Li, Daniel Kreisel
1aDepartment of Surgery bDepartment of Pathology & Immunology, Washington University in St. Louis, St. Louis, Missouri, USA.
Current Opinion in Organ Transplantation
|December 10, 2013
Summary
Innate immune cells play a dual role in transplanted tissue immunity, potentially causing rejection or promoting tolerance. New therapeutic targets are emerging, but require careful consideration for transplant recipients.
Area of Science:
- Immunology
- Transplantation Biology
- Innate Immunity
Background:
- Innate immune cells are crucial in the body's response to foreign entities.
- Their specific roles in transplanted tissue immunity are complex and multifaceted.
- Recent advancements have shed light on their involvement in transplant outcomes.
Purpose of the Study:
- To review current literature on innate cell involvement in transplanted tissue immunity.
- To focus on the impact of monocytes/macrophages, neutrophils, natural killer cells, and platelets.
- To identify potential therapeutic targets within the innate immune system for transplant recipients.
Main Methods:
- Comprehensive literature search of recent studies.
- Analysis of research focusing on innate immune cell function in transplantation.
- Synthesis of findings regarding immune response modulation.
Main Results:
- Innate immunity exhibits a dual role in transplanted tissue response, influencing both rejection and tolerance.
- Certain innate cells demonstrate the capacity to recognize allogeneic cells, a function previously thought exclusive to adaptive immunity.
- Specific innate cell populations significantly impact transplant survival and function.
Conclusions:
- The innate immune system presents novel therapeutic targets for managing transplant recipients.
- Careful investigation and cautious application of these therapeutics are essential.
- Understanding innate cell dynamics is key to improving transplant success rates.
Related Concept Videos
01:40Cell-mediated Immune Responses
64.7K
Overview
64.7K
01:28Cells of the Innate Immune Response
8.4K
The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
8.4K
01:23Cells of the Adaptive Immune Response
6.9K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
6.9K
01:24Tissue Transplantation
1.4K
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
1.4K
01:21Introduction to Innate and Adaptive Immunity
10.9K
The human immune system is a complex defense mechanism that protects the body from harmful pathogens and foreign substances. It comprises two crucial components: innate and adaptive immunity.
Innate immunity is the body's natural, nonspecific defense system that acts quickly to protect against pathogens. It incorporates physical barriers like skin and mucous membranes and cellular elements such as phagocytes and natural killer cells. This part of our immune system provides an immediate,...
Innate immunity is the body's natural, nonspecific defense system that acts quickly to protect against pathogens. It incorporates physical barriers like skin and mucous membranes and cellular elements such as phagocytes and natural killer cells. This part of our immune system provides an immediate,...
10.9K
01:27Cytotoxic T Cells-mediated Immune Response
7.0K
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
7.0K