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Published on: May 10, 2016
Cytotoxic activity of new phenolic compounds from Vietnamese Caesalpinia sappan
Tran Manh Hung1, Nguyen Xuan Hai, Nguyen Trung Nhan
1Faculty of Chemistry, University of Science, Vietnam National University.
Abstract:
Two new phenolic compounds, caesalpiniaphenols G-H (1 and 2), were isolated from Vietnamese Caesalpinia sappan heartwood. The chemical structures were established mainly by extensive spectroscopic studies and chemical evidence. Compounds 1 and 2 showed potent inhibitory activity against HL-60 cancer cell lines with respective IC50 values of 16.7 and 22.5 µg/mL. Treating HL-60 cells with various concentrations of 1 resulted in growth inhibition and the induction of apoptosis.
