Related Experiment Video
Updated: May 5, 2026

Murine Excisional Wound Healing Model and Histological Morphometric Wound Analysis
Published on: August 21, 2020
Updates on morphea: role of vascular injury and advances in treatment
Julio C Sartori-Valinotti1, Megha M Tollefson, Ann M Reed
1The Department of Dermatology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.
Abstract:
Morphea and systemic sclerosis are fibrosing disorders of the skin that share common inflammatory and immunologic pathways that are responsible for the vascular changes, increased collagen production, and extracellular matrix proliferation seen in both conditions. Recent advances in molecular biology techniques have furthered our knowledge of the potential underlying pathogenic mechanisms and offer new and provocative areas of research for novel diagnostic and therapeutic interventions. This review focuses on the role of vascular injury in the development of morphea, the use of ultrasonography as a diagnostic modality, and well-established and newly proposed treatments.
Related Concept Videos
Healing II: Complications
Varicose Veins II: Diagnostic Studies and Interprofessional Care
Tissue Injury: Inflammation and Repair
Cytotoxic Edema: Pathophysiology
Vascular Spasm
Phases of Wound Repair
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...

