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Updated: May 5, 2026
Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering
Published on: July 27, 2022
The use of nanocomposite coatings with various physicochemical properties in tissue engineering
A N Gol'tsev1, I V Rassokha, T G Dubrava
1Institute for Problems of Cryobiology and Cryomedicine, National Academy of Sciences of Ukraine, Khar'kov; National Science Center Kharkov Institute of Physics and Technology, National Academy of Science, Ukraine. cryopato@rambler.ru.
Abstract:
We studied the effect of nanocomposite coatings with various physicochemical properties on the structural and functional properties (adhesion potential, phenotype, gene expression) of mesenchymal stem cells. Of all tested nanocoatings (Al2O3, ZrO2, Ta2O5), oxide coating Al2O3 enriched in vitro monolayer bone marrow cell culture with cells carrying mesenchymal stem cells phenotype markers and stimulated expression of ido gene, which can confer new therapeutic potencies to these cells and extend their application in clinical practice.
