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Influence of histone-chondroitin sulphate A complexes on blood platelet aggregation
The influence of histones and their complexes with chondroitin sulphate A on platelet aggregation was studied. Histones F1 and F2a1 and complex histone F1-chondroitin sulphate A do not induce platelet aggregation by themselves but they decreased threshold aggregating concentration of ADP whereas complex histone F2a1-chondroitin sulphate A increased it. The results of our study may point out to the possibility of the examined substances taking part in disturbances of the platelet function.
The influence of histones and their complexes with chondroitin sulphate A on platelet aggregation was studied. Histones F1 and F2a1 and complex histone F1-chondroitin sulphate A do not induce platelet aggregation by themselves but they decreased threshold aggregating concentration of ADP whereas complex histone F2a1-chondroitin sulphate A increased it. The results of our study may point out to the possibility of the examined substances taking part in disturbances of the platelet function.