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Updated: May 5, 2026

Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury
Published on: May 27, 2022
Traumatic brain injury and PTSD screening efforts evaluated using latent class analysis
Hilary J Aralis1, Caroline A Macera1, Mitchell J Rauh1
1Warfighter Performance Department, Naval Health Research Center.
Routine military health screenings may miss many service members with persistent postconcussive symptoms. Identifying these individuals is crucial for accurate diagnosis and treatment of neurological and mental health conditions.
Area of Science:
- Military health
- Neuroscience
- Psychiatry
Background:
- Service members returning from deployment are screened for health issues.
- Persistent postconcussive symptoms and mental health conditions like PTSD are common concerns.
- Current screening methods may not fully capture the prevalence of these conditions.
Purpose of the Study:
- To identify distinct patterns of persistent postconcussive symptoms in service members.
- To compare these symptom patterns with screening results for PTSD and mild traumatic brain injury (TBI).
- To inform policy and improve treatment decisions for postdeployment health.
Main Methods:
- Latent class analysis of self-report data from 12,581 male service members.
- Utilized persistent postconcussive symptoms from Post-Deployment Health Assessments (PDHA) and Reassessments (PDHRA).
- Identified four classes: systemic, cognitive/behavioral, comorbid, and nonpresenting.
Main Results:
- Four distinct symptom classes were identified, varying in neurological and mental health symptom endorsement.
- The comorbid class reported a wide range of symptoms across both domains.
- Estimated probable neurological injury at 17.9%, higher than the 13.1% positive mild TBI screening rate.
Conclusions:
- Current PDHA and PDHRA may underestimate the prevalence of postdeployment health problems.
- Additional screening items or alternative algorithms focusing on postconcussive symptoms are needed.
- Improved identification can lead to more service members receiving necessary treatment.
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