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A text messaging intervention to promote medication adherence for patients with coronary heart disease: a randomized
Linda G Park1, Jill Howie-Esquivel2, Misook L Chung3
1San Francisco VA Medical Center, Division of Geriatrics, Palliative and Extended Care, USA.
Insights
Text messages (TM) improved adherence to antiplatelet medications in coronary heart disease patients. This mobile health intervention shows promise for enhancing medication adherence and secondary prevention.
Area of Science:
- Cardiology
- Digital Health
- Pharmacology
Background:
- Secondary prevention of coronary heart disease (CHD) is crucial for patient outcomes.
- Adherence to antiplatelet and statin therapy is vital for managing CHD.
- Mobile health interventions offer novel approaches to improve patient adherence.
Purpose of the Study:
- To compare antiplatelet and statin adherence in patients with CHD receiving different text message (TM) interventions.
- To evaluate the impact of medication reminders and education via TM on adherence.
- To assess the feasibility and satisfaction of a mobile health intervention for CHD patients.
Main Methods:
- A randomized controlled trial involving 90 CHD patients over 30 days.
- Utilized electronic monitoring (Medication Event Monitoring System - MEMS) to assess adherence.
- Analyzed adherence data using ANOVA and t-tests; self-reported adherence via Morisky Medication Adherence Scale.
Main Results:
- Patients receiving TM for antiplatelets showed significantly higher correct dose administration and adherence on schedule (p<0.05).
- TM response rates were higher for antiplatelets compared to statins (p=0.005).
- No significant differences in self-reported adherence were observed between groups.
Conclusions:
- Text message interventions significantly improved adherence to antiplatelet therapy, as confirmed by MEMS and TM response rates.
- Mobile health interventions are feasible, well-tolerated, and demonstrate potential for enhancing medication adherence in CHD management.
Objective:
Pharmacologic treatment for secondary prevention of coronary heart disease (CHD) is critical to prevent adverse clinical outcomes. In a randomized controlled trial, we compared antiplatelet and statin adherence among patients with CHD who received: (1) text messages (TM) for medication reminders and education, (2) educational TM only, or (3) No TM.
Methods:
A mobile health intervention delivered customized TM for 30 days. We assessed and analyzed medication adherence with electronic monitoring devices [Medication Event Monitoring System (MEMS)] by one-way ANOVA and Welch tests, two-way TM response rates by t-tests, and self-reported adherence (Morisky Medication Adherence Scale) by Repeated Measures ANOVA.
Results:
Among 90 patients (76% male, mean age 59.2 years), MEMS revealed patients who received TM for antiplatelets had a higher percentage of correct doses taken (p=0.02), percentage number of doses taken (p=0.01), and percentage of prescribed doses taken on schedule (p=0.01). TM response rates were higher for antiplatelets than statins (p=0.005). Self-reported adherence revealed no significant differences among groups.
Conclusion:
TM increased adherence to antiplatelet therapy demonstrated by MEMS and TM responses.
Practice Implications:
Feasibility and high satisfaction were established. Mobile health interventions show promise in promoting medication adherence.
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