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BDNF in quinolinic acid lesioned rats after bone marrow cells transplant
T Serrano Sánchez1, E Alberti Amador1, L Lorigados Pedre1
1International Center for Neurological Restauration (CIREN), Ave 25 # 15805 entre 158 y 160, Cubanacán, Playa, La Habana, Cuba.
Abstract:
Brain-derived neurotrophic factor (BDNF) concentration was measured in the striatum and cortex after quinolinic acid intrastriatal lesion and transplantation of bone marrow cells (BMSC). The results showed a significant increase of the BDNF levels in the striatum and cortex of the lesioned animals and the ability of the transplanted cells to increase the levels of BDNF in both sites. This recovery of BDNF production and distribution might have beneficial effects and ameliorate the negative consequences of the striatal lesion, a mechanism of potential interest for the treatment of Huntington's disease (HD).
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