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Updated: May 5, 2026

Using Retinal Imaging to Study Dementia
Published on: November 6, 2017
Different adenosine A2A receptor expression in peripheral cells from elderly patients with vascular dementia and
Cristina Gussago1, Beatrice Arosio1, Martina Casati2
1Geriatric Unit, University of Milan, Fondazione Ca' Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy Department of Medical Sciences and Community Health, University of Milan, Geriatrics, Milan, Italy.
Abstract:
The line between vascular dementia (VaD) and Alzheimer's disease (AD) is often blurred. In this study we investigated whether adenosine A2A receptor (A2AR) expression can be used to differentiate between VaD and AD. We evaluated the expression of this receptor in the peripheral blood mononuclear cells of patients with VaD, mild cognitive impairment, AD, and controls. We found statistically significant lower levels of A2AR mRNA in VaD compared to AD subjects. These data suggest that A2AR expression may help in the differential diagnosis between VaD and AD.
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