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Related Concept Videos

Fibronectins Connect Cells with ECM01:25

Fibronectins Connect Cells with ECM

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Fibronectin is an adhesive glycoprotein present in the extracellular matrix of embryogenic and adult tissue. These molecules primarily aid in regulating cell motility and attachment. A fibronectin molecule is composed of two identical polypeptide chains attached to each other by a pair of disulfide bonds at the C-terminal.
Both proteoglycans and collagen are attached to fibronectin proteins, which, in turn, are attached to integrin proteins. These integrin proteins interact with transmembrane...
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Fibril-associated Collagen01:11

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Fibril-associated collagens are a type of collagens present in the extracellular matrix with interrupted triple helices or FACIT (Fibril-associated collagens interrupted triple-helices). FACIT help connect and attach the collagen fibrils with each other as well as with other proteins of the extracellular matrix.
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
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Sutures of the Skull01:22

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The human skull is composed of several bones that come together to protect the brain and support the structures of the face. The junctions where these bones meet are called sutures.
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Clot Retraction and Fibrinolysis01:16

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After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.
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Structural Joints: Fibrous Joints01:03

Structural Joints: Fibrous Joints

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Fibrous joints are a type of joint where the bones are connected by fibrous connective tissue. These joints provide stability and minimal to no movement between the articulating bones. There are three types of fibrous joints.
Suture
All the bones of the skull, except for the mandible, are joined to each other by a fibrous joint called a suture. The fibrous connective tissue found at a suture strongly unites the adjacent skull bones and thus helps to protect the brain and form the face. In...
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Fractures: Bone Repair01:27

Fractures: Bone Repair

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Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
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Updated: May 5, 2026

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model
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Fibronectin and craniofacial surgery.

Mohammad M Al-Qattan1, Feras AlShomer, Abdullah Alqahtani

  • 1From the Division of Plastic Surgery, King Saud University, Riyadh, Saudi Arabia.

Annals of Plastic Surgery
|December 11, 2013
PubMed
Summary

Fibronectin, a key extracellular matrix protein, plays a vital role in craniofacial development and surgery. This review highlights its function in bone differentiation, neural crest cell migration, and tissue repair for craniofacial defects.

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Area of Science:

  • Extracellular matrix biology
  • Craniofacial development
  • Surgical innovation

Background:

  • Fibronectin is a crucial extracellular matrix protein.
  • Its specific roles in craniofacial surgery have not been comprehensively reviewed.
  • Fibronectin influences bone differentiation, skull development, and neural crest cell migration.

Purpose of the Study:

  • To review the multifaceted roles of fibronectin in craniofacial surgery.
  • To explore fibronectin's involvement in craniofacial development and disease.
  • To highlight fibronectin's potential in regenerative medicine for craniofacial applications.

Main Methods:

  • Literature review of studies on fibronectin in craniofacial development and surgery.
  • Analysis of fibronectin expression patterns in normal and pathological craniofacial conditions.
  • Examination of fibronectin's application in bone defect repair and stem cell technology.

Main Results:

  • Fibronectin is essential for skull and facial skeleton development, mediating neural crest cell migration.
  • Altered fibronectin levels are observed in craniofacial syndromes like Apert, Crouzon, and Sturge-Weber.
  • Imbalances in fibronectin are linked to cleft lip/palate development.
  • Fibronectin facilitates cell attachment in calvarial defect repair and serves as a carrier for bone morphogenetic proteins.
  • Fibronectin is integral to stem cell applications in craniofacial surgery.

Conclusions:

  • Fibronectin is indispensable for normal craniofacial development and plays significant roles in various craniofacial pathologies.
  • Its involvement in cell-mediated repair and regenerative medicine underscores its therapeutic potential in craniofacial surgery.
  • Further research is warranted to fully elucidate fibronectin's complex functions and therapeutic applications in the craniofacial region.