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A pyrene derivative for Hg(2+) -selective fluorescent sensing and its application in in vivo imaging
Guang Ke Wang1, Qi Li Mi, Li Yun Zhao
1Key Laboratory of Medicinal Chemistry for Natural Resource, School of Chemical Science and Technology, Yunnan University, Kunming 650091 (China), Fax: (+86) 871-65033679.
Abstract:
An Hg(2+) -selective fluorescent sensor (1) bearing pyrene as a fluorophore was synthesized. A sandwich-stacking binding mode was formed during the binding process, which increased the excimer fluorescence 22-fold at 490 nm. Compound 1 was successfully applied in in vivo imaging to trace the enrichment and distribution of mercury in the nervous system, digestive system, and reproductive system of Caenorhabditis elegans, as well as the organs of zebrafish.
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